June 2012 - The globally rising need for and use of medicines continues unabated. In the context of an ever widening range of medicinal therapies and a constantly growing number of pharmaceutical substances, interactions between bioactive substances are very significant. In the past, interactions between drugs and micronutrients received little attention in pharmaceutical and medical practice, but now medication-induced disturbances of micronutrient status are leading to a number of undesirable pharmacological effects. More-over, concomitant food intake can reinforce or diminish the bioavailability and effect of a pharmaceutical substance. In some cases, synergistic effects can arise from interactions between pharmaceuticals and micronutrients: micronutrients may complement medicinal treatment and enhance its effectiveness or reduce potential side-effects.

May 2012 - Observational studies and randomized controlled trials have examined the cardiovascular effects of fatty fish consumption and long-chain omega-3 polyunsaturated fatty acids (PUFAs) from dietary supplements. Several clinical trials have documented significant benefits of omega-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), for cardiovascular health. Although much has been learned, some questions remain unanswered, including: what are the precise physiological effects and molecular mechanisms that account for the observed benefits for cardiovascular health; and what are the magnitudes and dose-responses of effects on specific diseases and the potential differences in various populations? National and international guidelines now give consistent recommendations for the general population: to consume at least 250 mg/day of long-chain n-3 PUFA or at least two servings of oily fish per week (1, 2).

April 2012 - Chronic, low-grade, tissue inflammation is a significant risk factor in the development of a variety of chronic diseases, such as cardiovascular disease, cancer, diabetes, osteoporosis, arthritis, Alzheimer’s disease, and auto-immune diseases. Moreover, many discomforts, such as chronic pain, memory problems, mood swings, and general muscle fatigue, can be connected in some way to an underlying inflammatory condition. An important development in nutritional science in recent years has been the discovery of anti-inflammatory properties of certain micronutrients and their potential to prevent or treat certain diseases or conditions.