expert opinion
Comment on the US Institute of Medicine’s vitamin D recommendations released November 30, 2010
Most evidence on vitamin D and calcium concerns bone health.
Most evidence on vitamin D and calcium concerns bone health.
Several research approaches, particularly observational studies, suggest that diets rich in antioxidant nutrients (esp. vitamins C and E, beta-carotene, and selenium), and/or supplements containing one or more of these nutrients, are associated with a reduction in the risk of several age-related chronic diseases (e.g. some forms of cancer, cardiovascular, eye, and neurodegenerative diseases).
"Cognitive decline in the elderly is a significant public health issue. Oxidative stress and inflammation are believed to be involved in the pathogenesis of cognitive decline.
“As part of a randomized, placebo-controlled study, B-vitamins (25 mg vitamin B6, 2.5 mg vitamin B9 plus 1 mg vitamin B12 daily) were administered to 238 diabetics to explore whether these vitamins slow the progression of damage to the kidneys caused by diabetes (diabetic nephropathy) and prevent cardiovascular diseases (1).
Prof. Dr. med. vet. K. Pietrzik, Institute for Nutrition and Food Sciences Dept. of Nutritional Pathophysiology, Rheinische Friedrich-Wilhelms-University Bonn, Germany
“Last week a study appeared online in the American Journal of Clinical Nutrition that raised some eyebrows (1). The Swedish observational study followed approximately 35,000 women (aged 49 to 83 when the study began in 1997).
“The publication under discussion (1) involves the combined evaluation of 2 placebo-controlled, double-blind, randomized clinical studies (RCTs): NORVIT, Norwegian Vitamin Trial (2), and Western Norway B Vitamin Intervention Trial (3).
“The headline ‘The dark side of vitamin C’ recently appeared in the German newspaper service ‘Die Welt online,’ prompted by an American study showing that artificial antioxidants (N-acetyl cysteine and Trolox) support the metabolism of tumor cells that have become detached from the tumor and could thus promote metastasis.”
“A study published recently, which followed 161,808 women from the Women's Health Initiative over eight years, claimed to provide ‘convincing evidence that multivitamin use has little or no influence on the risk of common cancers, cardiovascular disease, or total mortality in postmenopausal women.’ This message was immediately sent around the world by the news media, leading people everywhere to believe that taking a daily multivitamin does no good and is a waste of money. Is it, really? Actually, nothing could be further from the truth.”
“Every micronutrient unfolds a specific effect in the human organism. These effects are complex, sometimes dose-dependent and can vary from one type of tissue or organ to another;