21 August 2013
A new review from New Zealand suggests that there is little to no evidence that supplementation with antioxidants, such as vitamins E and C, improves women's chances becoming pregnant.
The review analyzed data from 28 trials involving a total of 3,548 women many of whom underwent fertility treatment, including taking antioxidant supplements (e.g., vitamins, amino acids and/or omega-3 fatty acids) to try to increase their chances of becoming pregnant (1). The analysis showed that women taking anti-oxidants did not significantly increase their chances of conceiving or having a baby, compared to those taking placebos or being given standard treatment, including folic acid. Women taking antioxidants exper-ienced no more adverse effects compared to those who received placebos or standard treatment.
Overall, the researchers considered the quality of the analyzed trials to be of a low standard. They pointed out that the number of different antioxidants tested made it difficult to compare efficacies of each substance. Future trials may provide another result, the scientists noted. Oxidative stress has been identified as playing a key role in the development of subfertility in both males and females (2). While adverse effects of oxi-dative stress on sperm quality and functions have been well documented, in females its impact on oocytes and reproductive functions remains unclear. This imbalance between pro-oxidants and antioxidants can lead to a number of reproductive diseases such as endometriosis, polycystic ovary syndrome (PCOS), and unex-plained infertility. Antioxidant supplementation may be effective in controlling oxidative stress and continues to be explored as a potential strategy to overcome reproductive disorders associated with infertility.
8 September 2015
A new study from Australia reports that an omega-3 fatty acid supplementation of patients with recent onset rheumatoid arthritis seems to reduce the risk of anti-rheumatic drug failure.
1 May 2012
Observational studies and randomized controlled trials have examined the cardiovascular effects of fatty fish consumption and long-chain omega-3 polyunsaturated fatty acids (PUFAs) from dietary supplements. Several clinical trials have documented significant benefits of omega-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), for cardiovascular health. Although much has been learned, some questions remain unanswered, including: what are the precise physiological effects and molecular mechanisms that account for the observed benefits for cardiovascular health; and what are the magnitudes and dose-responses of effects on specific diseases and the potential differences in various populations? National and international guidelines now give consistent recommendations for the general population: to consume at least 250 mg/day of long-chain n-3 PUFA or at least two servings of oily fish per week (1, 2).
19 August 2009
Vitamin D may inhibit the build-up of cholesterol in blood vessels improving heart health of diabetics, says in vitro study.
