A new review from China reports that higher blood concentrations of vitamin D may protect against bladder cancer.
The systematic review and meta-analysis included a total of 89,610 participants, 2238 bladder cancer cases and their 25-hydroxyvitamin D serum concentrations (1). The analysis showed that participants with higher serum 25-hydroxyvitamin D levels suffered from an up to 25% reduced risk of subsequent bladder cancer. This statistic did not change when removing any single study from the analysis.
The researchers commented that vitamin D has important biological functions including modulation of the immune system and anti-cancer effects. Bladder cancer is a relatively rare cancer in which most cases occur in the cells that form the inner lining of the bladder. In the United States in 2014, there were an estimated 74,700 new diagnoses and 15,600 deaths from bladder cancer.