The preventive effect of adequate magnesium intake on developing type 2 diabetes appears to vary depending on genetic variations and ethnicity, reports a new US study.
The observational study analyzed magnesium intake, cases of type 2 diabetes, and specific genetic variations in 7,287 African-American women and 3,285 Hispanic women between the ages of 50 and 79 (1). The study results showed that the participants’ risk of developing type 2 diabetes varied depending on magnesium intake, genetic variations (polymorphisms) in magnesium-related ion channel genes, and ethnicity. For example, among Hispanic women with low magnesium intake, certain single-nucleotide polymorphisms were associated with an increased risk of diabetes. Among African-American women with high magnesium intake, one specific gene variation was found to have a diabetes-protective effect.
The researchers commented that earlier large prospective studies of men and women have already associated increased magnesium intake with a lower risk of type 2 diabetes (2). The absorption of magnesium (Mg2+) relies on ion channels coded by genes of which several single-nucleotide polymorphisms are known. Such genetic variations in ion channels can significantly influence the body’s magnesium supply and glucose metabolism, and are associated with the risk of developing type 2 diabetes (3). A sufficient intake of magnesium may partially compensate for magnesium deficiency caused by such genetic mutations. Further confirmation of these recent observations is needed from future mechanistic studies, the scientists noted.