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Vitamin B6 may decrease heart disease risk

Published on

02 February 2010

Low levels of vitamin B6 may increase the risk of cardiovascular disease, says a new study.

The study with 1,205 people found that higher levels of pyridoxal-5'-phosphate (PLP), the active form of vitamin B6, were linked to lower levels of C-reactive protein (CRP), a marker of inflammation, as well as lower levels of 8-OHdG, a marker for oxidative stress, both of which are related to heart disease risk (1).

CRP is produced in the liver and is a known marker for inflammation. Increased levels of CRP are a good predictor for the onset of both type-2 diabetes and cardiovascular disease.

Vitamin B6 may influence cardiovascular disease risk through mechanisms other than the reduction of the amino acid homocysteine, the researchers commented.


  1. Shen J. et al. Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study. American Journal of Clinical Nutrition. 2010; 91(2):337–342.

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