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      Vitamin B9 // Folic Acid

      References

      REFERENCES

      1. Food and Nutrition Board, Institute of Medicine. Folic Acid. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy Press; 1998:193–305.
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      22. Cole BF, Baron JA, Sandler RS, et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA. 2007; 297(21):2351–2359.
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      28. Alzheimer's, see in Alzheimer disease: findings from the Nun study. Am J Clin Nutr. 2000; 71(4):993–998.
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      38. Kauwell GP, Wilsky CE, Cerda JJ, et al. Methylenetetrahydrofolate reductase mutation (677C-->T) negatively influences plasma homocysteine response to marginal folate intake in elderly women. Metabolism. 2000; 49(11):1440–1443.
      39. De Bree A et al., Folate intake in Europe: recommended, actual and desired intake, European Journal of Clinical Nutrition 51 (1997) 643–660.
      40.  Nationale Verzehrsstudie II, 2008 (www.was-esse-ich.de), Max-Rubner-Institut, Karlsruhe, Germany.
      41. EC Scientific Committee on Food, Opinion of Scientific Committee on Food on the tolerable upper intake level of folate, European Commission 28.11.2000.
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      49. Figueiredo J. C.et al. Folic Acid and Risk of Prostate Cancer: Results From a Randomized Clinical Trial. 2009; 101:432–435.
      50. Ebbing M et al, Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA, 2009; 302(19); 2119-2126
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      52. European Food Safety Authority, Scientific Committee on Food. Tolerable Upper Intake Levels for Vitamins and Minerals. 2006: ISBN: 92-9199-014-0.
      53. Herrmann W. and Obeid R.: Functions and Deficiencies of B-Vitamins (and Their Prevention). International Encyclopedia of Public Health: ETH - HER. 2017, p199-203.
      54. Obeid R, Oexle K, Rißmann A, Pietrzik K, Koletzko B.: Folate status and health: challenges and opportunities. J Perinat Med. 2016 Apr;44(3):261-8. doi: 10.1515/jpm-2014-0346. Review.
      55. Tian, Tao; Yang, Kun-Qi; Cui, Jin-Gang; Zhou, Lan-Lan; Zhou, Xian-Liang: Clinical Investigation: Folic Acid Supplementation for Stroke Prevention in Patients With Cardiovascular Disease: A Meta-analysis. The American Journal of the Medical Sciences. Mar 2017
      56. Zhang Q, Wang Y, Xin X, Zhang Y, Liu D, Peng Z, He Y, Xu J, Ma X: Effect of folic acid supplementation on preterm delivery and small for gestational age births: A systematic review and meta-analysis.Reprod Toxicol. 2017 Jan;67:35-41. doi: 10.1016/j.reprotox.2016.11.012. Epub 2016 Nov 14
      57. Zhao M, Wu G, Li Y, Wang X, Hou FF, Xu X, Qin X, Cai Y: Meta-analysis of folic acid efficacy trials in stroke prevention: Insight into effect modifiers. Neurology. 2017 May 9;88(19):1830-1838. doi: 10.1212/WNL.0000000000003909. Epub 2017 Apr 12
      58. Li MM, Yu JT, Wang HF, Jiang T, Wang J, Meng XF, Tan CC, Wang C, Tan L.Efficacy of vitamins B supplementation on mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis. Curr Alzheimer Res. 2014;11(9):844-52.
      59. Chen H, Liu S, Ji L, Wu T, Ji Y, Zhou Y, Zheng M, Zhang M, Xu W, Huang G.: Folic Acid Supplementation Mitigates Alzheimer's Disease by Reducing Inflammation: A Randomized Controlled Trial. Mediators Inflamm. 2016;2016:5912146. doi: 10.1155/2016/5912146. Epub 2016 Jun 2.
      60. Chen P, Li C, Li X, Li J, Chu R, Wang H.: Higher dietary folate intake reduces the breast cancer risk: a systematic review and meta-analysis. Br J Cancer. 2014 Apr 29;110(9):2327-38. doi: 10.1038/bjc.2014.155. Epub 2014 Mar 25. Review.
      61. Araújo JR, Martel F, Borges N, Araújo JM, Keating E.Folates and aging: Role in mild cognitive impairment, dementia and depression. Ageing Res Rev. 2015 Jul;22:9-19. doi: 10.1016/j.arr.2015.04.005. Epub 2015 May 2. Review
      62. Stamm RA, Houghton LA.Nutrient intake values for folate during pregnancy and lactation vary widely around the world. Nutrients. 2013 Sep 30;5(10):3920-47. doi: 10.3390/nu5103920. Review.
      63. Selhub J, Rosenberg IH: Excessive folic acid intake and relation to adverse health outcome. Biochimie. 2016 Jul;126:71-8. doi: 10.1016/j.biochi.2016.04.010. Epub 2016 Apr 27. Review.

      Authored by Dr Peter Engel in 2010, reviewed and revised by  Angelika Friedel on 29.06.2017