Supported by science, omega-3 EPA + DHA can deliver real benefits to your patients

A large and growing body of evidence shows that insufficient levels of omega-3 EPA + DHA can lead to serious consequences.
Learn more about the research behind the importance of omega-3s and how patients can benefit from increasing intake.

Promotion of healthy living in the United States

Harvard researchers evaluated the mortality effects of several dietary, lifestyle and metabolic risk factors in the United States. They found that insufficient levels of omega-3 were associated with serious health complications and nearly 100,000 premature deaths each year.1

Effect of fish oil on cardiac health

A systematic review published in the British Medical Journal looking at the effects of fish oil supplementation included 12 studies with a total of nearly 33,000 patients. The review concluded that fish oil supplementation was associated with a significant reduction in deaths from cardiac causes.2

Fish intake and coronary function

In a study evaluating the risks and benefits of fish intake published in JAMA, researchers found that 1-2 servings of fish per week, especially fish high in the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), reduced the risk of coronary death by 36% and total mortality by 17%.3

Promotion of a healthy cardiac function

A cohort study published in Annals of Internal Medicine followed 2,692 US adults age 65+ without prevalent CHD at baseline. Higher baseline plasma phospholipid concentrations of omega-3 fatty acids was associated with decreased risk of total mortality and fewer cardiovascular events.4 These findings are consistent with those of other cohorts from around the world.5

Improvement in endothelial function

A study published in Athersclerosis evaluated the effect of omega-3 supplementation in the offspring of patients with type 2 diabetes. Omega-3 supplementation was found to improve endothelial function and reduce biomarkers of inflammation in these subjects. This suggests that increased omega-3 intake may have beneficial cardiovascular and metabolic health effects.6

NOTE: The studies and findings presented are those of the authors and were not conducted on behalf of the Know Your Ω™ initiative or DSM Nutritional Products. In no way do the authors or their body of work endorse any products or the Know Your Ω™ initiative. These materials are for informational purposes only. Any recommendations made therein are not intended to act as medical advice and should not be regarded as such.


Put omega-3s into practice with fact sheets, patient materials and more.

About: Know Your Ω™

By 2030, it’s estimated that nearly 44% of U.S. adults will have some form of cardiovascular disease – a leading cause of death among both men and women.3

Omega-3 EPA + DHA can help reduce the overall risk of cardiovascular disease and protect against heart health risks.5 Know Your Ω™, an educational campaign by DSM Nutritional Products, recognizes the vital role that healthcare practitioners play in addressing the vast inadequacy of omega-3 intake among the U.S. population. Know Your Ω™ is a resource that supports omega-3 recommendations to help protect your patients from cardiovascular disease and other health risks.

Know Your Ω™ is a trademark of DSM.


  1. Danaei G, Ding E, Ezzati M et al. The preventable causes of death in the United States: Comparative risk assessment of dietary, lifestyle, and metabolic risk factors. PLoS Med. 2009;6:e1000058. doi: 10.1371/journal.pmed.1000058.
  2. Leon H, Shibata MC, Sivakumaran S, Dorgan M, Chatterley T, Tsuyuki RT. Effect of fish oil on arrhythmias and mortality: systematic review. BMJ. 2008;337:a2931. doi: 10.1136/bmj.a2931.
  3. Mozaffarian D, Rimm EB. Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA. 2006;296:1885-99. doi: 10.1001/jama.296.15.1885.
  4. Mozaffarian D, Lemaitre Rn, King IB et al. (2013). Plasma phospholipid long-chain ω-3 fatty acids and total and cause-specific mortality in older adults: a cohort study. Annals of Internal Medicine. 2013;158:515-25. doi: 10.7326/0003-4819-158-7-201304020-00003.
  5. Del Gobbo LC, Imamura F, Aslibekyan S et al. ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies. JAMA Internal Medicine. 2016;176:1155-66. doi: 10.1001/jamainternmed.2016.2925.
  6. Rizza S, Tesauro M, Cardillo C et al. Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes. Atherosclerosis. 2009;206:569-74. doi: 10.1016/j.atherosclerosis.2009.03.006.
  7. Mozaffarian D, Benjamin EJ, Go AS et al. Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation. 2016;133:e38-e360. doi: 10.1161/CIR.0000000000000350.

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