• News
  • 2012

Low vitamin D levels may increase risk of heart disease

Published on

03 October 2012

According to a new Danish study, low vitamin D concentrations in the blood seem to be associated with a significantly higher risk of heart attack and early death.

To investigate a potential link between vitamin D levels and the incidence of heart disease and mortality, the researchers measured 25-hydroxyvitamin D – 25(OH)D – concentrations in blood samples from 10,170 wo-men and men and documented cases of heart disease and premature death for an average of 29 years (1). In addition to this, a meta-analysis, including 18 studies investigating the risk of ischemic heart disease and 17 studies looking at vitamin D and early death, was performed. The study results showed that low levels of vitamin D (less than 15 nM vitamin per liter serum) in comparison to healthy levels (more than 50 nmol/liter) were linked to a 40% higher risk of ischemic heart disease, a 64% higher risk of heart attack, a 57% higher risk of early death, and an 81% higher risk of death from heart disease. The meta-analysis showed that the risk of ischemic heart disease and early death were increased by 39% and 46% for participants with the lowest 25(OH)D levels versus those with the highest concentrations.

The researchers noted that the findings of this population study can not determine anything definitive about a possible causal relationship. However, they added that the results indicate a strong statistical correlation between a low level of vitamin D and a high risk of heart disease and early death. An explanation may be that a low vitamin D level leads directly to heart disease and death, or that vitamin D deficiency is a marker for poor health in general. Results from several earlier population studies have already indicated that a low blood vitamin D concentration may be linked to a higher risk of ischemic heart disease, while other studies have shown that vitamin D deficiency may increase blood pressure.


  1. Brøndum-Jacobsen, P. et al. 25-Hydroxyvitamin D Levels and Risk of Ischemic Heart Disease, Myocardial Infarction, and Early Death: Population-Based Study and Meta-Analyses of 18 and 17 Studies. Arteriosclerosis, Thrombosis and Vascular Biology. Published online September 2012.

This site uses cookies to store information on your computer.

Learn more

This site uses cookies to store information on your computer.

Learn more