Throughout the years, the emphasis of vitamin research has shifted from mainly fighting deficiencies towards health promotion and disease treatment. However, the relationship between diet and multifactorial diseases is very complex, and experiments trying to measure micronutrient effects by applying standard methods used for drug testing seem to be only partially suitable (see also Principles – The contradictory science of micronutrients).
High-dose vitamins are not ‘magic bullets’ capable of replacing standard medical therapies. However, in some cases the treatment of diseases with high-dose vitamins, some of them also registered as drugs, has shown promising results. As a rule, randomized controlled trials are needed in order to provide substantiated, well-observed effects.
Any dietary or drug treatment with high-dose micronutrients needs medical supervision.