Tags

Strong scientific evidence for omega-3 fatty acids to decrease arterial stiffness

Published on

13 July 2011

According to a new meta-analysis from Australia, long-chain n-3 fatty acids significantly reduce arterial stiffness. That may account for some of its evident cardioprotective effects. The findings provide compelling evidence for supplementation with long-chain n-3 PUFA to increase arterial flexibility.

The first systematic review and meta-analysis conducted on this subject included ten randomized controlled trails with omega-3 fatty acids – eicosapentanioc acid (EPA) and docosahexanoic acid (DHA) – investigating the benefits of n-3 fatty acids on arterial stiffness (1). A recent meta-analysis of 17 longitudinal studies confirmed aortic stiffness as a significant predictor of future cardiovascular events and all-cause mortality. Arterial stiffness is also related to brain and kidney end-organ damage. Reducing arterial stiffness may reduce related risks, particularly of cardiovascular diseases (CVD). The authors of the study aimed to assess the scientific evidence for n-3 PUFA in the treatment of arterial stiffness. They reviewed four trials that were exploring the chronic effects of long-chain n-3 PUFA on pulse wave velocity (PWV). Another six trials were reviewed as respective outcome measures; these used arterial compliance, measured as capacitive compliance or systemic arterial compliance.

The authors concluded that the meta-analysis provides compelling evidence that supplementation with mega-3 fatty acids offers a scientifically supported means of reducing arterial stiffness. They found that the n-3 PUFA were effective in independently improving both PWV and arterial compliance with small-to-moderate clinical effects. And they resume: “As increased arterial stiffness is a risk factor for CVD, n-3 supplementation may provide a means of reducing the risk of CVD and end-organ damage.”

REFERENCES

  1. Pase M.P. et al. Do long-chain n-3 fatty acids reduce arterial stiffness? A meta-analysis of randomised controlled trials. BJN 2011.

This site uses cookies to store information on your computer.

Learn more

This site uses cookies to store information on your computer.

Learn more